Memphis will play its first two games in Little Rock, which is about as close to a home-court advantage as a number one seed could ask for. If seeding form holds, the Tigers will take Mississippi State in the second round. Cowbells, anyone?
If the Tigers get through to the Sweet 16, they'll play in Houston, where they'll likely face either Pitt or Michigan State, and then Texas. National experts are calling Memphis' road to the Final Four the most difficult of any of the Number One seeds.
The other number one seeds were Kansas, North Carolina and UCLA.
What do you think? How far will the Tigers go? Give us your predictions in the comments section below.