Shawn Taggart added 15 points and seven rebounds to help the Tigers (11-0) match the second-best start in school history, dating to the 1982-83 season.
Chase Budinger had 20 points, and Jordan Hill battled foul trouble to score 14 for the Wildcats (9-3), whose six-game winning streak ended.
Memphis coach John Calipari scheduled tougher opponents this season to help offset the Conference USA schedule his Tigers begin playing in January. Apparently it hasn't been tough enough, since Memphis has rolled through the thick of its daunting nonconference schedule this season much like it has through C-USA in years past: untouched.
The Tigers already have defeated three ranked opponents - Arizona, Georgetown, Southern California - as well as perennial powers Oklahoma, Connecticut and Cincinnati.